In order to save his dying father, young stunt cyclist Johnny Blaze sells his soul to Mephistopheles and sadly parts from the pure-hearted Roxanne Simpson, the love of his life. Years later, Johnny's path crosses again with Roxanne, now a go-getting reporter, and also with Mephistopheles, who offers to release Johnny's soul if Johnny becomes the fabled, fiery 'Ghost Rider'.

In order to foil a terrorist plot, an FBI agent undergoes facial transplant surgery and assumes the identity of a criminal mastermind. The plan turns sour when the criminal wakes up prematurely and seeks revenge.