Following a ridiculously awful flight that leads to his pet's death, Nashawn Wade files a lawsuit against the airline, and wins a multimillion-dollar settlement. Determined to create a better flying experience, Nashawn starts his own airline, one that caters to an African-American clientele. Going into business with a tricked-out plane piloted by the smooth Capt. Mack, the airline hits a snag when it has to deal with the family of Elvis Hunkee.

FBI agent Neville Flynn boards a flight from Honolulu, Hawaii to Los Angeles, escorting a key witness to testify against a mob boss at an upcoming trial. An on-board assassin releases a crate full of hundreds of deadly venomous snakes in an attempt to eliminate the witness. Flynn and a host of frightened passengers and crew must band together to survive the slithery threat.