Seymour Krelborn is a nerdy orphan working at Mushnik's; a flower shop in urban Skid Row. He harbors a crush on fellow co-worker, Audrey Fulquard, and is berated by Mr. Mushnik daily. One day, Seymour finds a very mysterious unidentified plant which he calls Audrey II. The plant seems to have a craving for blood and soon begins to sing for it’s supper.

Mutated by his own secret formula, Dr. Alec Holland becomes Swamp Thing, a half-human, half-plant superhero who will stop at nothing to rescue government agent Alice Cable and defeat his evil arch nemesis...even if it costs him his life.