When car dealer Charlie Babbitt learns that his estranged father has died, he returns home to Cincinnati, where he discovers that he has a savant older brother named Raymond and that his father's $3 million fortune is being left to the mental institution in which Raymond lives. Motivated by his father's money, Charlie checks Raymond out of the facility in order to return with him to Los Angeles. The brothers' cross-country trip ends up changing both their lives.

Slacker duo Beavis and Butt-Head wake to discover their TV has been stolen. Their search for a new one takes them on a clueless adventure across America, during which they manage to accidentally become America's most wanted.