San Francisco Bay, January 18, 1960. Frank Lee Morris is transferred to Alcatraz, a maximum security prison located on a rocky island. Although no one has ever managed to escape from there, Frank and other inmates begin to carefully prepare an escape plan.

When vengeful General Francis X. Hummel seizes control of Alcatraz Island and threatens to launch missiles loaded with deadly chemical weapons into San Francisco, only a young FBI chemical weapons expert and notorious Federal prisoner have the skills to penetrate the impregnable island fortress and take him down.