Amid a future war between the human race and the forces of artificial intelligence, a hardened ex-special forces agent grieving the disappearance of his wife, is recruited to hunt down and kill the Creator, the elusive architect of advanced AI who has developed a mysterious weapon with the power to end the war—and mankind itself.

Finding himself in a new era, and approaching retirement, Indy wrestles with fitting into a world that seems to have outgrown him. But as the tentacles of an all-too-familiar evil return in the form of an old rival, Indy must don his hat and pick up his whip once more to make sure an ancient and powerful artifact doesn't fall into the wrong hands.