Each year, three brothers Samuel, Jeffrey and Michael Douglas visits their Japanese grandfather, Mori Shintaro whom the boys affectionately refer to as Grandpa, for the summer. Mori is a highly skilled in the fields of Martial arts and Ninjutsu, and for years he has trained the boys in his techniques. After an organized crime ring proves to be too much for the FBI, it's time for the 3 brother NINJAS! To use their martial arts skills, they team up to battle the crime ring and outwit some very persistent kidnappers!

After years of being sheltered from the human world, the Turtle brothers set out to win the hearts of New Yorkers and be accepted as normal teenagers through heroic acts. Their new friend April O'Neil helps them take on a mysterious crime syndicate, but they soon get in over their heads when an army of mutants is unleashed upon them.