Retired from active duty, and training recruits for the Impossible Mission Force, agent Ethan Hunt faces the toughest foe of his career: Owen Davian, an international broker of arms and information, who's as cunning as he is ruthless. Davian emerges to threaten Hunt and all that he holds dear – including the woman Hunt loves.

Ethan Hunt and his team are racing against time to track down a dangerous terrorist named Hendricks, who has gained access to Russian nuclear launch codes and is planning a strike on the United States. An attempt to stop him ends in an explosion causing severe destruction to the Kremlin and the IMF to be implicated in the bombing, forcing the President to disavow them. No longer being aided by the government, Ethan and his team chase Hendricks around the globe, although they might still be too late to stop a disaster.